BOTOX Cosmetic is the most popular FDA-approved treatment for moderate to severe frown lines between the brows and crow's feet lines in adults. The medicine is injected into the muscles, blocking the contractions that cause wrinkles and temporarily reducing lines around your eyes. You may begin to notice smoother skin within 24 to 48 hours following your treatment session and results will last approximately 4 months. BOTOX is proven to be one of the most effective and safe products for reducing unwanted signs of aging on your face.