Feel confident in your body

Feel confident in your body

QWO - Collagenase Clostridium Histolyticum-aaes Injection

QWO is the first and only FDA-approved non-surgical injectable for the treatment of moderate to severe cellulite in the buttock of adult women.

Treatment consists of three QWO treatments, one every 3 weeks. Injections take 10 minutes or less. In clinical trials, no post-treatment downtime was required.
There are 3 primary structural factors associated with the appearance of cellulite.:

  • Fibrous septae that tether the dermis to the deep fascia
  • Fat lobules that are segmented by fibrous septae and push against the skin
  • The dermis becoming thinner

QWO is made from enzymes called collagenases. These enzymes are thought to target the structural causes under the skin, where cellulite starts. It's thought that QWO works by releasing fibrous bands, redistributing fat cells, and stimulating the growth of new collagen. The best description of the treatment process would be QWO causes Enzymatic Subcision and Remodeling (ESR). QWO enzymatically subcizes the fibrous septae, reorganizes fat lobules, and initiates neocollagenesis and helps thicken the dermis. Desired results may be achieved in 28 days following the 3rd treatment. No post treatment downtime is required.

Bruising at the injection site is expected which could last 3 weeks with residual discoloration for a couple of months. Each subsequent treatment will cause less bruising. The injection causes a breakdown of the small superficial blood vessels that surround the collagen that is being released. Other potential side effects are pain, areas of hardness, itching, redness, swelling and warmth at the treatment area.

Endo Aesthetics conducted the largest clinical trials in the history of cellulite investigation to help determine the safety and efficacy of QWO. All skin types and ethnicities were studied.

Cellulite FAQS

What is cellulite?

Cellulite is a localized alteration in the contour of the skin that has been reported in approximately 90% of adult women of all races and ethnicities.

What causes cellulite?

Over time, three completely normal things can happen. Fat cells get larger, skin gets thinner and a little looser and the fibrous bands under the skin's surface get thicker, leading to a dimpled appearance.

Who gets cellulite?

Women are more likely to have cellulite than men,3 and it affects women of all shapes, sizes, ages and races.

Why aren't men prone to developing cellulite?

Men have thicker skin than women do, and their collagen bands are oriented in a crisscross fashion, essentially eliminating the ability
of the fat lobules to bulge through. If a man is given estrogen hormones (as in some cancer treatments), they can develop cellulite if there is enough fat.

Are fat and cellulite the same?

Fat is not cellulite and does not cause it, but fat cells getting bigger between fibrous bands under the skin can contribute to a bumpy appearance.

Can weight loss help get rid of cellulite?

Weight loss might reduce the appearance of cellulite but won't get rid of it since it doesn't address the fibrous bands under the skin's surface. In some cases, weight loss can actually make cellulite look worse because of resulting skin laxity.

Do topical treatments help decrease the appearance of cellulite?

Topical treatments such as lotions, creams and scrubs have been used to temporarily reduce the appearance of cellulite.

What body parts are most prone to cellulite?

In an online Harris Poll survey of 2,006 women with cellulite, respondents said their cellulite was most commonly present in certain areas: 81% thighs, 66% butt, 42% stomach, 33% hips, 24% arms, 11% calves. Although cellulite can develop in various areas of the body, it mainly affects women and the predominant localization is on thighs and buttocks. This is because women tend to have more fatty deposits in these areas.

How does age impact the appearance of cellulite?

Skin laxity happens as you age and can impact the appearance of cellulite.